
By Nicole McEwen, Lifescript Staff Writer
Published September 15, 2009
Patrick Swayze’s battle with pancreatic cancer ended yesterday when the beloved actor, best known for his roles in Dirty Dancing and Ghost, passed away at age 57. However, the disease doesn’t just strike men – women are at risk too.
How common is pancreatic cancer?
Pancreatic cancer is rare, striking 5 out of every 100,000 annually or about 42,000 Americans, according to the American Cancer Society. It occurs nearly twice as often in men as women, but pancreatic cancer is still the fifth leading cause of death for women in the U.S. It’s the fourth leading cause of death for men.
Because pancreatic cancer is hard to diagnose and treat, the mortality rate is high. About 35,000 Americans die from the disease every year.
Research shows the average person has a 1% chance of getting pancreatic cancer, says Robert McWilliams, M.D., an oncologist at the Mayo Clinic in Rochester, Minn. That risk doubles to 2% if someone in the family has the condition. As the baby boomer generation nears retirement age, the number of people afflicted with pancreatic cancer is expected to rise. Overall though, pancreatic cancer tends to strike the elderly. Most are just over 70 years of age when diagnosed. Only 20% are under 60.
What causes pancreatic cancer?
Like other forms of cancer, pancreatic cancer is caused by mutations in DNA. Genetics, a poor diet and/or smoking may play a role in triggering the mutations. It typically starts in the tissues of the pancreas but may spread to the liver, lymph nodes and other surrounding areas.
As many as 20 different tumors have been found to grow on and around the pancreas. Each is different and may require different treatment.
Where is the pancreas and what does it do?
Your pancreas is the large organ behind the lower part of the stomach. It secretes enzymes that aid digestion and hormones that help regulate sugar metabolism.
“The pancreas is the geographic center of your body,” says Scott Kern, Ph.D., an associate professor of oncology and pathology and pancreatic cancer researcher at the Sol Goldman Pancreatic Cancer Research at Johns Hopkins in Baltimore, Md. “You can’t see it, you can’t feel it, and normal secretions can’t be seen without special equipment.”
What are the symptoms of pancreatic cancer?
Unfortunately, symptoms usually don’t appear until the disease is advanced, McWilliams says. That’s mainly due to the pancreas’ hidden location and behind-the-scenes role in bodily functions. When symptoms do surface, they include:
Upper abdominal pain
Yellowing of the skin and whites of the eyes (jaundice)
Loss of appetite
Weight loss
Depression
What are the risk factors?
Researchers know this much: Men and women are at equal risk for pancreatic cancer. But certain factors could put you at increased risk:
Smoking
Obesity
Family history of multiple pancreatic cancers
Diet high in animal fat
History of chronic inflammation of the pancreas (pancreatitis)
Smoking accounts for 25%-30% of pancreatic cancers. Cigarettes – or any burning tobacco product – release a chemical that can cause healthy cells to turn cancerous, says an International Journal of Cancer study.
Several studies show that obesity can raise the risk of pancreatic cancer by as much as 60%. A study conducted by the Women’s Health Initiative reported that obese people – those with a body-mass index over 30 – have increased levels of insulin, which may cause the disease.
In particular, abdominal fat can raise your risk, says Rachel Stolzenberg-Solomon, M.D., a researcher at the National Cancer Institute’s Division of Cancer Epidemiology and Genetics in Bethesda. A British Journal of Cancer study reported that obese women who carry most of their weight around their belly are 70% more likely to develop the disease than those whose weight is more evenly distributed.



